Pulmonary infection with the bacterium Yersinia pestis causes pneumonic plague, an often-
fatal disease for which no vaccine is presently available. Antibody-mediated humoral …

Yersinia pestis and many other Gram-negative pathogenic bacteria use the
chaperone/usher (CU) pathway to assemble virulence-associated surface fibers termed pili …

Earlier, we reported the identification of new virulence factors/mechanisms of Yersinia pestis
using an in vivo signature-tagged mutagenesis (STM) screening approach. From this …

Virulence of Yersinia pestis in mammals requires the type III secretion system, which
delivers seven effector proteins into the cytoplasm of host cells to undermine immune …

ABSTRACT A delayed inflammatory response is a prominent feature of infection with
Yersinia pestis, the agent of bubonic and pneumonic plague. Using a rat model of bubonic …

Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of
bubonic and pneumonic plague. Y. pestis is capable of causing major epidemics; thus, there …

Yersinia pestis, the causative agent of plague, possesses a number of virulence
mechanisms that allows it to survive and proliferate during its interaction with the host. To …

Publisher Summary Bubonic plague caused by Yersinia pestis ranks as the most severe
bacterial disease known to humanity. In the mouse, this bleak process consists of an initial …

Yersinia species display a tropism for lymphoid tissues during infection, and the bacteria
select innate immune cells for delivery of cytotoxic effectors by the type III secretion system …

Human polymorphonuclear leukocytes (PMNs, or neutrophils) are the most abundant innate
immune cell and kill most invading bacteria through combined activities of reactive oxygen …