Plague, a zoonotic disease transmitted from rodents via fleabites, caused three large
pandemics, each decimating human populations with profound effects on civilization. What …

In an effort to identify the novel virulence determinants of Yersinia pestis, we applied the
gene “discovery” methodology, in vivo-induced (IVI) antigen technology, to detect genes …

Yersinia pestis causes pneumonic plague, a necrotic pneumonia that rapidly progresses to
death without early treatment. Antibodies to the protective antigen LcrV are thought to …

Yersinia pestis causes bubonic plague, characterized by an enlarged, painful lymph node,
termed a bubo, that develops after bacterial dissemination from a fleabite site. In susceptible …

To establish a successful infection, Yersinia pestis requires the delivery of cytotoxic Yops to
host cells. Yops inhibit phagocytosis, block cytokine responses, and induce apoptosis of …

We are using a systemic plague model to identify the cells and pathways that are
undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this …

Yersinia pestis, a Gram-negative bacterium that causes bubonic and pneumonic plague, is
able to rapidly disseminate to other parts of its mammalian hosts. Y. pestis expresses …

Yersinia pestis causes pneumonic plague, an exceptionally virulent disease for which we
lack a safe and effective vaccine. Antibodies specific for the Y. pestis F1 and LcrV proteins …

Yersinia pestis is a Gram-negative, faculta-tive anaerobic, rod-shaped and nonspore-
forming coccobacillus, which is better known as the causative agent of the bubonic plague …

The ability of Yersinia pestis to forestall the mammalian innate immune response is a
fundamental aspect of plague pathogenesis. In this study, we examined the effect of Ail, a 17 …