Unlocking ancient protein palimpsests

E Cappellini, MJ Collins, MTP Gilbert - Science, 2014 - science.org
Over the past 30 years, ancient DNA studies have grown from a scientific curiosity into a
powerful research tool with applications in molecular evolution, archaeology, paleontology …

Ancient protein analysis in archaeology

J Hendy - Science Advances, 2021 - science.org
The analysis of ancient proteins from paleontological, archeological, and historic materials is
revealing insights into past subsistence practices, patterns of health and disease, evolution …

A guide to ancient protein studies

J Hendy, F Welker, B Demarchi, C Speller… - Nature ecology & …, 2018 - nature.com
Palaeoproteomics is an emerging neologism used to describe the application of mass
spectrometry-based approaches to the study of ancient proteomes. As with palaeogenomics …

A comparison of common mass spectrometry approaches for paleoproteomics

TP Cleland, ER Schroeter - Journal of Proteome Research, 2018 - ACS Publications
The last two decades have seen a broad diversity of methods used to identify and/or
characterize proteins in the archeological and paleontological record. Of these, mass …

Protein molecular data from ancient (> 1 million years old) fossil material: pitfalls, possibilities and grand challenges

MH Schweitzer, ER Schroeter, MB Goshe - Analytical chemistry, 2014 - ACS Publications
Advances in resolution and sensitivity of analytical techniques have provided novel
applications, including the analyses of fossil material. However, the recovery of original …

Paleoproteomics: an introduction to the analysis of ancient proteins by soft ionisation mass spectrometry

M Buckley - Paleogenomics: Genome-Scale Analysis of Ancient …, 2019 - Springer
The field of proteomic research, analogous to genomic research, has only recently
witnessed a rapid increase in its application to the study of ancient materials. Bone has been …

Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Molecular technology in paleontology and paleobiology: Applications and limitations

AA Abdelhady, B Seuss, S Jain, D Fathy, M Sami… - Quaternary …, 2024 - Elsevier
In the last 5 decades, paleontological research has exploded where fossils have enabled
robust dating of rocks, improved understanding of origination/extinction rates or mass …

Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry

JM Asara, MH Schweitzer, LM Freimark, M Phillips… - Science, 2007 - science.org
Fossilized bones from extinct taxa harbor the potential for obtaining protein or DNA
sequences that could reveal evolutionary links to extant species. We used mass …

Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins

E Cappellini, LJ Jensen, D Szklarczyk… - Journal of proteome …, 2012 - ACS Publications
We used high-sensitivity, high-resolution tandem mass spectrometry to shotgun sequence
ancient protein remains extracted from a 43 000 year old woolly mammoth (Mammuthus …