Meta analysis of candidate gene variants outside the LPA locus with Lp (a) plasma levels in 14,500 participants of six White European cohorts
BACKGROUND: Both genome-wide association studies and candidate gene studies have
reported that the major determinant of plasma levels of the Lipoprotein (a)[Lp (a)] reside …
reported that the major determinant of plasma levels of the Lipoprotein (a)[Lp (a)] reside …
Genetic predictor to identify individuals with high lipoprotein (a) concentrations
Recent advances in drug development aim to transi-tion lipoprotein (a)(Lp [a]) from a
predictive biomarker of cardiovascular disease to a therapeutic target. Among those with …
predictive biomarker of cardiovascular disease to a therapeutic target. Among those with …
Multiple QTL influence the serum Lp (a) concentration: a genome-wide linkage screen in the PROCARDIS study
S Barlera, C Specchia, M Farrall, BD Chiodini… - European journal of …, 2007 - nature.com
The serum concentration of lipoprotein Lp (a) is known to be highly heritable and associated
with cardiovascular risk. A genome-wide variance component linkage analysis was …
with cardiovascular risk. A genome-wide variance component linkage analysis was …
Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report
M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
Phenotypic characterization of genetically lowered human lipoprotein (a) levels
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …
(a) levels in African Americans (AAs) are much higher compared with that in European …
Genome-wide association study of plasma lipoprotein (a) levels identifies multiple genes on chromosome 6q [S]
Plasma lipoprotein (a)(Lp [a]) level is an independent risk factor of cardiovascular disease
that is under strong genetic control. We conducted a genome-wide association study of …
that is under strong genetic control. We conducted a genome-wide association study of …