Accelerated vascular aging in chronic kidney disease: the potential for novel therapies
S Hobson, S Arefin, A Witasp, L Hernandez… - Circulation …, 2023 - Am Heart Assoc
The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …
[HTML][HTML] Mechanisms of cardiovascular disorders in patients with chronic kidney disease: a process related to accelerated senescence
J Carracedo, M Alique, C Vida, G Bodega… - Frontiers in cell and …, 2020 - frontiersin.org
Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory
process such as atherosclerosis, remain the leading cause of morbidity and mortality in …
process such as atherosclerosis, remain the leading cause of morbidity and mortality in …
[HTML][HTML] The ageing kidney: Molecular mechanisms and clinical implications
Y Fang, AY Gong, ST Haller, LD Dworkin, Z Liu… - Ageing research …, 2020 - Elsevier
As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …
challenge for clinical practices. Human ageing is associated with molecular, structural, and …
[HTML][HTML] The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli
RJ Glassock, AD Rule - Kidney international, 2012 - Elsevier
Aging is both a natural and inevitable biological process. With advancing age, the kidneys
undergo anatomical and physiological changes that are not only the consequences of …
undergo anatomical and physiological changes that are not only the consequences of …
[HTML][HTML] The aging kidney
XJ Zhou, D Rakheja, X Yu, R Saxena, ND Vaziri… - Kidney international, 2008 - Elsevier
Renal aging, by itself, is associated with alterations in renal morphology and a decline in
renal function, which is accelerated and/or accentuated by diseases such as diabetes …
renal function, which is accelerated and/or accentuated by diseases such as diabetes …
Chronic kidney disease and premature ageing
JP Kooman, P Kotanko, AMWJ Schols… - Nature Reviews …, 2014 - nature.com
Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …
[HTML][HTML] Molecular mechanisms of renal aging
R Schmitt, A Melk - Kidney international, 2017 - Elsevier
Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …
Renal aging: causes and consequences
ED O'Sullivan, J Hughes… - Journal of the American …, 2017 - journals.lww.com
Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving …
the developed world. Consequently, more aged patients than before are receiving …
Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage
L Dai, LJ Schurgers, PG Shiels… - Nephrology Dialysis …, 2020 - academic.oup.com
Chronic kidney disease (CKD) is a clinical model of premature ageing characterized by
cardiovascular disease, persistent uraemic inflammation, osteoporosis muscle wasting and …
cardiovascular disease, persistent uraemic inflammation, osteoporosis muscle wasting and …
[HTML][HTML] Pathophysiology of the aging kidney and therapeutic interventions
K Kanasaki, M Kitada, D Koya - Hypertension Research, 2012 - nature.com
Kidneys are among the organs affected by the aging process. Aging kidneys are
characterized by progressive scarring and measurable declines in renal function …
characterized by progressive scarring and measurable declines in renal function …