Aging is a physiological process that causes structural and functional changes in human
body systems, sometimes leading to various organ failure. As far as the kidney is concerned …

Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality
of life and survival. Current treatment options are highly inadequate. As kidney function …

The process of normal aging affects organ homeostasis as well as responses to acute and
chronic injury. In view of the rapid growth in the elderly population, it is increasingly …

This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …

The kidney undergoes age-related changes, reaching full functionality after the age of 5
years and suffering a slow but progressive decline in its regulatory range of function (eg …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

The kidneys exhibit age-associated deterioration in function via a loss of 20% to 25% kidney
mass, particularly from the renal cortex and increased fibrosis. Oxidative stress has been …

Preclinical and clinical studies suggest that specific subsets of cells isolated from the
peripheral blood, play an essential role in the imbalance of damage and repair during age …

Age-associated loss of kidney function has been recognized for decades. With aging, many
subjects exhibit progressive decreases in glomerular filtration rate and renal blood flow, with …

Cellular senescence contributes to the decline in renal function during aging and defective
regeneration in kidney diseases. Further insight into the underlying molecular mechanisms …