Background Peripheral vascular diseases may induce chronic ischemia and cellular injury
distal to the arterial obstruction. Cellular senescence involves proliferation arrest in …

The structure and function of arteries change throughout a lifetime. Age is the dominant risk
factor for hypertension, coronary heart disease, congestive heart failure, and stroke. The …

The varied functions of the kidneys are influenced by the complex process of aging. The
glomerular filtration rate (GFR) steadily declines with normal aging, and the progress of this …

Chronic kidney disease (CKD) has been shown to be associated with high oxidative stress
and cardiovascular disease. In this chapter our focus will be on the role of advanced …

Chronic kidney disease (CKD) patients are among the groups at the highest risk for
cardiovascular disease and significantly shortened remaining lifespan. CKD enhances …

Age-associated changes of the kidney are important not only because normal ageing alters
renal function but also because of the high frequency of end-stage renal disease in the …

Kidney function declines with age in the majority of the population. Although very few older
people progress to end stage, the consequences of doing so are burdensome for the patient …

Chronic kidney disease (CKD), and particularly kidney failure, is associated with accelerated
atherosclerosis and approximately a 20-fold increased risk of cardiovascular death. The …

Cardiovascular disease is the leading cause of death in patients with end-stage renal
disease. Although the prevalance of traditional atherosclerotic risk factors is increased in …

Accelerated cardiovascular disease is a frequent complication of renal disease. Chronic
kidney disease promotes hypertension and dyslipidemia, which in turn can contribute to the …