Imidazolidine derivatives were studied as anti-Trypanosoma cruzi agents. Imidazolines can
be considered as ethylenediamine/carbonyl precursors and therefore interfere with the …

Chagas disease is caused by infection with the intracellular protozoan parasite
Trypanosoma cruzi. At present, nifurtimox and benznidazole, both compounds developed …

We modified the thiazolidinic ring at positions N3, C4, and C5, yielding compounds 6–24.
Compounds with a phenyl at position N3, 15–19, 22–24, exhibited better inhibitory …

Chagas disease (CD), caused by the intracellular protozoan Trypanosoma cruzi, is a
parasitic illness endemic in Latin America. In the centennial after CD discovery by Carlos …

Arylimidamides (AIAs) have been shown to have considerable biological activity against
intracellular pathogens, including Trypanosoma cruzi, which causes Chagas disease. In the …

Chagas disease (CD), a neglected tropical disease caused by Trypanosoma cruzi, remains
a serious public health problem in several Latin American countries. The available …

The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz),
is unsatisfactory. In this context, we performed the phenotypic in vitro screening of novel …

New heteroallyl-containing 5-nitrofuranes were synthesized as potential anti-Trypanosoma
cruzi agents with a dual mechanism of action, oxidative stress and inhibition of membrane …

Five bis-arylimidamides were assayed as anti-Trypanosoma cruzi agents by in vitro, in silico,
and in vivo approaches. None were considered to be pan-assay interference compounds …

The antiparasitic activity of azole and new 4-aminopyridine derivatives has been
investigated. The imidazoles 1 and 3–5 showed a potent in vitro antichagasic activity with …