[HTML][HTML] Stepwise withdrawal of inhaled corticosteroids in COPD patients receiving dual bronchodilation: WISDOM study design and rationale

H Magnussen, H Watz, A Kirsten, M Decramer… - Respiratory …, 2014 - Elsevier
Long-acting bronchodilators in combination with inhaled corticosteroids (ICS) are
recommended to decrease the risk of recurrent exacerbations in patients with Global …

Discontinuation of inhaled corticosteroids from triple therapy in COPD: effects on major outcomes in real world clinical practice

S Suissa, S Dell'Aniello, P Ernst - COPD: Journal of Chronic …, 2022 - Taylor & Francis
Recent reports provide evidence-based guidelines for the withdrawal of inhaled
corticosteroids (ICS) in COPD, but data on patients treated with ICS-based triple therapy are …

[HTML][HTML] Withdrawal of inhaled corticosteroids can be safe in COPD patients at low risk of exacerbation: a real-life study on the appropriateness of treatment in …

A Rossi, M Guerriero, A Corrado - Respiratory research, 2014 - Springer
Background It has been suggested that withdrawal of inhaled corticosteroids (ICS) in COPD
patients on maintenance treatment results in deterioration of symptoms, lung function and …

Optimizing de-escalation of inhaled corticosteroids in COPD: a systematic review of real-world findings

P Rogliani, BL Ritondo, M Gabriele… - Expert Review of …, 2020 - Taylor & Francis
Introduction To date, there is solid evidence from randomized controlled trials (RCTs)
supporting the rationale for withdrawal from inhaled corticosteroids (ICSs) in most patients …

Applying the wisdom of stepping down inhaled corticosteroids in patients with COPD: a proposed algorithm for clinical practice

AG Kaplan - … Journal of Chronic Obstructive Pulmonary Disease, 2015 - Taylor & Francis
Current guidelines for the management of chronic obstructive pulmonary disease (COPD)
recommend limiting the use of inhaled corticosteroids (ICS) to patients with more severe …

Real-life use of inhaled corticosteroids in COPD patients versus the GOLD proposals: a paradigm shift in GOLD 2011?

PR Burgel, G Deslée, G Jebrak… - European …, 2014 - Eur Respiratory Soc
Clinical trials in chronic obstructive pulmonary disease (COPD) patients have shown that the
long-term use of inhaled corticosteroids (ICS) in COPD patients reduced the number of …

[HTML][HTML] Withdrawal of inhaled glucocorticoids and exacerbations of COPD

H Magnussen, B Disse… - … England Journal of …, 2014 - Mass Medical Soc
Background Treatment with inhaled glucocorticoids in combination with long-acting
bronchodilators is recommended in patients with frequent exacerbations of severe chronic …

Weaning from inhaled corticosteroids in COPD: the evidence

S Suissa, A Rossi - European Respiratory Journal, 2015 - Eur Respiratory Soc
The use of inhaled corticosteroids (ICS) in the treatment of chronic obstructive pulmonary
disease (COPD) has been widely debated [1–3]. Treatment guidelines have suggested that …

Lung function changes over time following withdrawal of inhaled corticosteroids in patients with severe COPD

H Magnussen, K Tetzlaff, ED Bateman… - European …, 2016 - Eur Respiratory Soc
The combination of an inhaled long-acting β2-agonist with an inhaled corticosteroid (ICS) is
widely used in the management of chronic obstructive pulmonary disease (COPD), primarily …

Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis

DM Sobieraj, CM White, CI Coleman - Clinical therapeutics, 2008 - Elsevier
Background: Several clinical trials have evaluated the benefits associated with adding an
inhaled corticosteroid (ICS) to a long-acting bronchodilator in the treatment of severe or very …