Modification of cellular DNA upon exposure to reactive oxygen and nitrogen species is the
likely initial event involved in the induction of the mutagenic and lethal effects of various …

Oxidative DNA Damage: Endogenous and Chemically Induced - ScienceDirect Skip to main
contentSkip to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download …

Oxidative damage to DNA has been reported to occur in a wide variety of disease states.
The most widely used “marker” for oxidative DNA damage is 8-hydroxyguanine. However …

Publisher Summary Evidence is accumulating for the predominant involvement of singlet
oxygen (1 O 2) in the oxidation reactions of major cellular targets such as DNA and …

Reactive oxygen species, produced endogenously or by exposure to environmental
chemicals and ionizing radiation, induce a wide range of DNA lesions. The variety of …

The development of cancer in humans and animals is a multistep process. The complex
series of cellular and molecular changes participating in cancer development are mediated …

Deoxyribonucleic acid (DNA) appears to be a critical cellular target for the biological effects
(cellular lethality, mutagenesis, carcinogenesis, and ageing) of oxidation processes …

A major development of carcinogenesis research in the past 20 years has been the
discovery of significant levels of DNA damage arising from endogenous cellular sources …

When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular
mechanisms causing this damage may include activation of nucleases and direct reaction of …

The main purpose of this study was to determine whether well-known reactive oxygen
species (ROS)-generating agents can induce DNA damage in a simple chemical system …