Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma

RS Irwin, CT French, NA Smyrnios… - Archives of Internal …, 1997 - jamanetwork.com
Background: In diagnosing cough due to asthma, methacholine chloride inhalation
challenge (MIC) interpreted in a traditional fashion has been shown to have positive …

Wheezing on maximal forced exhalation in the diagnosis of atypical asthma: lack of sensitivity and specificity

DK King, BT Thompson, DC Johnson - Annals of internal medicine, 1989 - acpjournals.org
Study Objective: To determine whether wheezing on maximal forced exhalation is a
predictor of asthma in persons with normal or nearly normal baseline spirometry. Design …

Diagnosis of bronchial asthma by clinical evaluation: an unreliable method

MR Pratter, DM Hingston, RS Irwin - Chest, 1983 - Elsevier
To determine the predictive value of wheeze compared to methacholine inhalation
challenge (MIC) in diagnosing asthma, we prospectively evaluated 34 patients considered …

Clinical applicability of a methacholine inhalational challenge

JR Myers, WM Corrao, SS Braman - Jama, 1981 - jamanetwork.com
Cough, dyspnea, and chest pain are symptoms common to many cardiopulmonary
diseases. A comprehensive evaluation, including a history, physical examination, ECG …

Do physicians need objective measurements to diagnose asthma?

E Adelroth, FE Hargreave… - American Review of …, 1986 - atsjournals.org
The frequency with which disagreement occurs between the clinician's diagnosis of asthma
and the objective measurement of methacholine airway responsiveness is not known. We …

Asymptomatic bronchial hyperresponsiveness in rhinitis

EH Ramsdale, MM Morris, RS Roberts… - Journal of allergy and …, 1985 - Elsevier
Methacholine inhalation tests are used to help in the diagnosis of asthma when spirometry is
normal. However, the significance of increased methacholine responsiveness in patients …

From a prospective study of chronic cough: diagnostic and therapeutic aspects in older adults

NA Smyrnios, RS Irwin, FJ Curley… - Archives of internal …, 1998 - jamanetwork.com
Background Cough is the most common complaint for which adults see a physician in the
ambulatory setting in the United States. An anatomical diagnostic protocol has been used …

An algorithmic approach to chronic cough

MR Pratter, T Bartter, S Akers… - Annals of internal medicine, 1993 - acpjournals.org
Objectives: To evaluate a stepwise approach to chronic cough that emphasized initial
treatment of all patients with an antihistamine-decongestant for postnasal drip and to …

Airway inflammation in patients with symptoms suggesting asthma but with normal lung function

P Rytila, T Metso, K Heikkinen… - European …, 2000 - Eur Respiratory Soc
The hypothesis that eosinophilic airway inflammation is present in many patients presenting
with respiratory symptoms suggestive of asthma but with normal lung function was tested …

Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthma

A Di Franco, FL Dente, D Giannini, B Vagaggini… - Pulmonary …, 2001 - Elsevier
In asthmatic subjects cough can be related to the degree of airway inflammation. The aim of
this study was to evaluate the effect of treatment with high dose inhaled beclomethasone …