Cough-type asthma is a well-defined entity. The patients typically have a chronic,
nonproductive cough that is exacerbated by exercise and upper respiratory tract infections …

Background: Measurements of airway responsiveness are frequently used to evaluate anti-
asthma drugs. Objective: This study investigated the utility of methacholine airway …

Airway responsiveness assessed using histamine and methacholine is safe, reproducible
and relatively easily undertaken in adults and children. Results are similar for methacholine …

Study objectives Recent American Thoracic Society guidelines recommend two different
methods of methacholine challenge testing: the 2-min tidal breathing method with twofold …

Cough is frequently the presenting symptom of bronchial asthma, although cough can result
from a wide variety of other respiratory disease. Treatment of chronic cough has proved …

The pathophysiology of cough variant asthma is poorly understood. In particular, the
mechanisms that cause different symptoms in typical asthma (in which wheeze …

Six patients with chronic cough, without history of dyspnea or wheezing, had normal base-
line spirometry but hyper-reactive airways, as demonstrated with methacholine …

Two theories explaining the mechanism for the manifestation of cough without wheeze in
patients with cough variant asthma (CVA) are either a higher wheezing threshold or a milder …

On systematic investigation, patients with persistent cough are often diagnosed as having
asthma, gastro-oesophageal reflux (GOR) and post-nasal drip; often, there is no associated …

Twenty-two patients with only chronic nonproductive cough lasting for more than 2 months
were prospectively examined to determine whether airway cough receptor sensitivity and …