Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus

K Azuma, LK Heilbronn, JB Albu… - American Journal …, 2007 - journals.physiology.org
Insulin resistance (IR) is typically more severe in obese individuals with type 2 diabetes
(T2DM) than in similarly obese non-diabetics but whether there are group differences in …

Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

Y Miyazaki, L Glass, C Triplitt… - American Journal …, 2002 - journals.physiology.org
We examined the relationship between peripheral/hepatic insulin sensitivity and abdominal
superficial/deep subcutaneous fat (SSF/DSF) and intra-abdominal visceral fat (VF) in …

Body fat distribution, adipocyte size, and metabolic characteristics of nondiabetic adults

MS Mundi, MV Karpyak, C Koutsari… - The Journal of …, 2010 - academic.oup.com
Context: It is unclear whether adipocyte size or body fat distribution is most strongly linked to
the metabolic complications of obesity. Objective: Our objective was to test whether …

Evaluation of abdominal fat distribution in noninsulin-dependent diabetes mellitus: relationship to insulin resistance

JF Gautier, A Mourier, E de Kerviler… - The Journal of …, 1998 - academic.oup.com
Accumulation of visceral adipose tissue is associated with metabolic complications such as
noninsulin-dependent diabetes mellitus. The aim of this study was to evaluate the effect of …

Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women

BH Goodpaster, S Krishnaswami, H Resnick… - Diabetes …, 2003 - Am Diabetes Assoc
OBJECTIVE—We examined whether regional adipose tissue distribution, specifically that of
skeletal muscle fat and visceral abdominal fat aggregation, is characteristic of elderly …

Preferential Fat Deposition in Subcutaneous Versus Visceral Depots Is Associated with Insulin Sensitivity

T McLaughlin, C Lamendola, A Liu… - The Journal of Clinical …, 2011 - academic.oup.com
Background: Studies on the relationship between regional fat and insulin resistance yield
mixed results. Our objective was to determine whether regional fat distribution, independent …

Impact of different fat depots on insulin sensitivity: predominant role of liver fat

K Kirchhoff, K Kantartzis, J Machann… - Journal of diabetes …, 2007 - journals.sagepub.com
Background: Overall obesity and, as it is increasingly appreciated, body fat distribution and
ectopic fat deposition in liver and skeletal muscle, determine insulin resistance in humans …

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

A Hammarstedt, TE Graham, BB Kahn - Diabetology & metabolic syndrome, 2012 - Springer
Abstract Background Obesity contributes to Type 2 diabetes by promoting systemic insulin
resistance. Obesity causes features of metabolic dysfunction in the adipose tissue that may …

Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type

Y Miyazaki, RA DeFronzo - Cardiovascular diabetology, 2009 - Springer
Background All previous studies that investigated the association between abdominal fat
distribution and insulin resistance evaluated subcutaneous and visceral fat area and/or …

Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity

SK Gan, AD Kriketos, AM Poynten, SM Furler… - Obesity …, 2003 - Wiley Online Library
Objective: Abdominal fat and myocyte triglyceride levels relate negatively to insulin
sensitivity, but their interrelationships are inadequately characterized in the overweight …