Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

The p53 protein plays a critical role in the prevention of genome mutations in the body,
however, this protein is frequently mutated in cancer and almost all cancers exhibit …

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell
growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its …

Conspectus Prion-like behavior of several amyloidogenic proteins has been demonstrated
in recent years. Despite having functional roles in some cases, irregular aggregation can …

Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …

Liquid–liquid phase separation (LLPS) has emerged in recent years as an important
physicochemical process for organizing diverse processes within cells via the formation of …

Referred to as the “guardian of the genome”, p53 is the most frequently mutated protein in
cancer and almost all cancers exhibit malfunction along the p53 pathway. As an …

The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”;
however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity …

Intrinsically disordered domains represent attractive therapeutic targets because they play
key roles in cancer, as well as in neurodegenerative and infectious diseases. They are …