GLP-1R agonists for the treatment of obesity: a patent review (2015-present)

C Liu, Y Zou, H Qian - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
ABSTRACT Introduction Glucagon-like peptide-1 (GLP-1) is an endogenous peptide which
is secreted by enteroendocrine L cells, GLP-1 receptor agonists (GLP-1 RAs) can exhibit …

Investigational glucagon-like peptide-1 agonists for the treatment of obesity

B Tomlinson, M Hu, Y Zhang, P Chan… - Expert Opinion on …, 2016 - Taylor & Francis
Introduction: Obesity is a worldwide problem predisposing to type 2 diabetes mellitus
(T2DM), hypertension, cardiovascular disease, cancer and other comorbidities. Lifestyle …

Glucagon‐like peptide agonists: A prospective review

Z Mariam, SK Niazi - Endocrinology, Diabetes & Metabolism, 2024 - Wiley Online Library
Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as
promising therapeutic options for addressing Type‐2 diabetes, obesity, and related …

The antiobesity effect and safety of GLP-1 receptor agonist in overweight/obese patients without diabetes: a systematic review and meta-analysis

X Guo, Z Zhou, X Lyu, H Xu, H Zhu… - Hormone and …, 2022 - thieme-connect.com
Aim To determine the antiobesity effect and safety of glucagon-like peptide-1 receptor
agonist (GLP-1RA) including liraglutide, exenatide and semaglutide treatment in …

Role of glucagon-like peptide 1 receptor agonists in management of obesity

D Isaacs, L Prasad-Reddy… - American journal of …, 2016 - academic.oup.com
Purpose Published data on the weight loss effects of glucagon-like peptide 1 (GLP-1)
receptor agonists are reviewed, with a focus on data from clinical trials. Summary Obesity is …

Weight loss and maintenance related to the mechanism of action of glucagon-like peptide 1 receptor agonists

J Ard, A Fitch, S Fruh, L Herman - Advances in therapy, 2021 - Springer
Obesity is a chronic disease associated with many complications. Weight loss of 5–15% can
improve many obesity-related complications. Despite the benefits of weight reduction, there …

Obesity and GLP-1

APMDE Oca, S Pellitero… - Minerva …, 2021 - pubmed.ncbi.nlm.nih.gov
Obesity is an important public health issue that has been on the rise over the last decades. It
calls for effective prevention and treatment. Bariatric surgery is the most effective medical …

Glucagon-like peptide 1 receptor agonists: a medication for obesity management

MB Taha, T Yahya, P Satish, R Laird… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of Review The burden of obesity worldwide is high and projected to rise.
Obesity increases the risk of several cardiovascular diseases and cardiometabolic risk …

The GLP-1 agonist, liraglutide, as a pharmacotherapy for obesity

J Crane, B McGowan - Therapeutic advances in chronic …, 2016 - journals.sagepub.com
There is a global obesity epidemic that will continue to be a financial burden on healthcare
systems around the world. Tackling obesity through diet and exercise should always be the …

GLP-1 as a target for therapeutic intervention

SP Rajeev, J Wilding - Current opinion in pharmacology, 2016 - Elsevier
Highlights•GLP-1 analogues are used in the management of type 2 diabetes and
obesity.•They improve glycaemic control, promote weight loss and have a low risk of …