Biocompatibility and surface structure of chemically modified immunoisolating alginate‐PLL capsules

CM Bünger, C Gerlach, T Freier… - … Research Part A: An …, 2003 - Wiley Online Library
Grafting of encapsulated living cells has the potential to cure a wide variety of diseases.
Large‐scale application of the technique, however, is hampered by insufficient …

Tissue responses against immunoisolating alginate‐PLL capsules in the immediate posttransplant period

P De Vos, CG van Hoogmoed… - … Research: An Official …, 2002 - Wiley Online Library
Alginate‐polylysine (PLL) capsules are commonly applied for immunoisolation of living cells
for the treatment of a wide variety of diseases. Large‐scale application of the technique …

Chemistry and biocompatibility of alginate‐PLL capsules for immunoprotection of mammalian cells

P de Vos, CG Hoogmoed… - Journal of Biomedical …, 2002 - Wiley Online Library
Transplantation of encapsulated living cells is a promising approach for the treatment of a
wide variety of diseases. Large‐scale application of the technique, however, is hampered by …

Improvement of the biocompatibility of alginate/poly‐L‐lysine/alginate microcapsules by the use of epimerized alginate as a coating

A King, B Strand, AM Rokstad… - … Research Part A: An …, 2003 - Wiley Online Library
Abstract Alginate/poly‐l‐lysine (PLL)/alginate capsules are used widely for the
microencapsulation of cells. Alginate consists of guluronic acid and mannuronic acid, the …

Deletion of the tissue response against alginate-pll capsules by temporary release of co-encapsulated steroids

CM Bünger, B Tiefenbach, A Jahnke, C Gerlach… - Biomaterials, 2005 - Elsevier
Transplantation of encapsulated living cells is a promising approach for the treatment of a
wide variety of diseases. Large-scale application of the technique, however, is hampered by …

Adsorption of human immunoglobulin to implantable alginate‐poly‐L‐lysine microcapsules: Effect of microcapsule composition

SK Tam, BJ de Haan, MM Faas, JP Hallé… - … Research Part A: An …, 2009 - Wiley Online Library
Abstract Alginate‐poly‐l‐lysine‐alginate (APA) microcapsules continue to be the most
widely studied device for the immuno‐protection of transplanted therapeutic cells. Producing …

The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules

A King, S Sandler, A Andersson - Journal of Biomedical …, 2001 - Wiley Online Library
Microencapsulation of islets of Langerhans in alginate/poly‐l‐lysine (PLL)/alginate capsules
may provide a method for transplantation in the absence of immunosuppression. The aim of …

Microcapsules made by enzymatically tailored alginate

BL Strand, YA Mørch, KR Syvertsen… - … Research Part A: An …, 2003 - Wiley Online Library
Alginate is widely used for encapsulation of cells. Alginate is a linear block copolymer
consisting of mannuronic acid (M) and guluronic acid (G). It has been shown that enzymes …

Effect of poly‐L‐lysine coating on macrophage activation by alginate‐based microcapsules: Assessment using a new in vitro method

S Juste, M Lessard, N Henley… - Journal of Biomedical …, 2005 - Wiley Online Library
The characteristics of the microcapsule surface, which interacts directly with the host
macrophages, may have a role in the biocompatibility of alginate‐poly‐l‐lysine (PLL) …

Biocompatibility and physicochemical characteristics of alginate–polycation microcapsules

SK Tam, S Bilodeau, J Dusseault, G Langlois, JP Hallé… - Acta biomaterialia, 2011 - Elsevier
There is a need for better understanding of the biocompatibility of alginate–polycation
microcapsules based on their physicochemical characteristics. Microcapsules composed of …