Objective: SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP)
caused by mutations in the SPAST gene. HSP is considered an upper motor neuron …

SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP) caused by
mutations in the SPAST gene. HSP is considered an upper motor neuron disorder …

To determine the cortical mechanism that underlies the cognitive impairment and motor
disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family …

Mutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic
paraplegia, but the extent of the neurodegeneration related to the disease is not yet known …

SPG11 mutations are the major cause of autosomal recessive Hereditary Spastic
Paraplegia. The disease has a wide phenotypic variability indicating many regions of the …

Background SPG4 is a subtype of hereditary spastic paraplegia (HSP), an upper motor
neuron disorder characterized by axonal degeneration of the corticospinal tracts and the …

Hereditary spastic paraplegias (HSP) are a group of clinically and genetically
heterogeneous disorders with the hallmark of progressive spastic gait disturbance. We used …

The aim of this study was to identify potential diagnostic markers of Hereditary Spastic
Paraplegia (HSP). We investigated the white matter features of spastic gait (SPG) 11-and …

Hereditary spastic paraplegia (HSP) is a genetically heterogeneous group of
neurodegenerative disorders characterized by progressive lower extremity weakness and …

One of the most exciting insights from functional neuroimaging is the recognition of the
tremendously large capacity for structural and functional reorganization of the human brain …