Whooping cough is caused by the bacterium Bordetella pertussis. There are currently two
types of vaccines that can prevent the disease; whole cell vaccines (WCV) and acellular …

B. pertussis is a human-specific pathogen and the causative agent of whooping cough. The
ongoing resurgence in pertussis incidence in high income countries is likely due to faster …

Pertussis vaccines are routinely administered to infants to protect them from whooping
cough. Still, an adequate safety test for pertussis toxin (PT), one of the main antigens in …

The mouse histamine sensitization test (HIST) is the currently accepted regulatory method
used to monitor residual pertussis toxin (PTx) activity in acellular pertussis vaccines. This …

The quality control of acellular pertussis vaccines presents particular problems related to the
differences in composition and method of detoxification used in the various type of …

All acellular pertussis (aP) vaccines in use contain chemically inactivated pertussis toxin
(PT). The finding that mice, naturally resistant to the effects of histamine, become sensitive …

Because of the exquisite sensitivity of the murine histamine sensitization test (HIST) in
detecting minute amounts of active pertussis toxin (PTx), this animal-based test has been …

Two batches each of diphtheria-tetanus-acellular pertussis vaccine (DTaP) and that
combined with inactivated polio vaccine purchased from foreign markets were tested by …

A binding assay was recently published that differentiates between pertussis toxin (PTx) and
the pertussis toxoid (PTd) used in acellular pertussis vaccines based on the selective …

Vaccination is the most effective way to prevent infectious diseases. Recombinant DNA
technologies have provided powerful new tools to develop vaccines that were previously …