Repeated cold stress (RCS) can trigger the development of fibromyalgia (FM)-like
symptoms, including persistent deep-tissue pain, although nociceptive changes to the skin …

Fibromyalgia (FM) is a debilitating disease characterized by generalized and persistent
musculoskeletal pain. Although central mechanisms are strongly implicated in the …

Peripheral noxious stimulation evokes functional and biochemical changes in the spinal
cord which results in central sensitization and hyperalgesia, but at the same time also …

This study evaluated Fos-like immunoreactivity in lumbar spinal cord neurons following
intense cold stimulation and then the modifications induced by opioid administration. Under …

In order to clarify the central mechanisms of thermal hyperalgesia produced by peripheral
nerve injury, Fos protein-like immunoreactive (Fos-LI) cells in spinal dorsal horn neurons …

Background: Fibromyalgia (FM) is characterized by chronic widespread pain, which is often
refractory to conventional painkillers. Numerous clinical studies have demonstrated that …

We have previously demonstrated that repeated swim stress produces a long-lasting
cutaneous hyperalgesia in rats. We have now looked at c-Fos expression in the spinal …

The method of c-fos immunodetection was used to map the distributions of neurons in the
lumbar spinal dorsal horn that were activated following intracutaneous (ic) microinjection, or …

The purpose of this study was to investigate sex-related differences in nociception elicited by
sc injection of different concentrations (1–5%) of formalin. Sc formalin-induced biphasic …

The effect of graded inflammatory stimuli (intraplantar-carrageenan, 0.2, 1, and 6 mg/150 μl)
on paw edema and c-Fos protein expression at two levels of the spinoparabrachial pathway …