Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster

M Morey, F Serras, J Baguna, E Hafen… - Developmental …, 2001 - Elsevier
Modulation of reactive oxygen species (ROS) plays a key role in signal transduction
pathways. Selenoproteins act controlling the redox balance of the cell. We have studied how …

The {\it Drosophila}{\it selenophosphate synthetase (selD)} gene is required for development and cell proliferation

F Serras, M Morey, B Alsina, J Baguna… - Biofactors, 2001 - content.iospress.com
To study the function of selenoproteins in development and growth we have used a lethal
mutation ({\it selD [TeX:]^{\it ptuf}}) of the {\it Drosophila} homologous selenophosphate …

Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster

M Morey, F Serras, M Corominas - FEBS letters, 2003 - Wiley Online Library
Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants.
Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen …

Antioxidant function of a novel selenoprotein in Drosophila melanogaster

N Morozova, EP Forry, E Shahid, AM Zavacki… - Genes to …, 2003 - Wiley Online Library
Background: Insects appear to have diverged from both higher and lower organisms in their
defense mechanisms against oxidative damage. They do not encode glutathione …

DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila

M Morey, M Corominas, F Serras - Journal of cell science, 2003 - journals.biologists.com
The cellular antioxidant defense systems neutralize the cytotoxic by-products referred to as
reactive oxygen species (ROS). Among them, selenoproteins have important antioxidant …

Disruption of selenoprotein biosynthesis affects cell proliferation in the imaginal discs and brain of Drosophila melanogaster

B Alsina, M Corominas, MJ Berry… - Journal of Cell …, 1999 - journals.biologists.com
The patufet gene encodes the Drosophila melanogaster homologue of selenophosphate
synthetase, an enzyme required for selenoprotein synthesis, and appears to have a role in …

Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila

M Hirosawa‐Takamori, HR Chung, H Jäckle - EMBO reports, 2004 - embopress.org
Selenoprotein synthesis is conserved from bacteria to man. It involves the differential
decoding of the UGA stop codon as selenocysteine. The proteomes of both prokaryotes and …

Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion

A Hamieh, D Cartier, H Abid, A Calas, C Burel… - EMBO …, 2017 - embopress.org
Selenoprotein T (SelT) is a recently characterized thioredoxin‐like protein whose expression
is very high during development, but is confined to endocrine tissues in adulthood where its …

Selenoprotein dSelK in Drosophila elevates release of Ca2+ from endoplasmic reticulum by upregulating expression of inositol 1,4,5-tris-phosphate receptor

SB Ben, QY Wang, L Xia, JZ Xia, J Cui, J Wang… - Biochemistry …, 2011 - Springer
Abstract dSelK (G-rich), a homolog of human and mouse SelK, is one of three
selenoproteins in Drosophila melanogaster. It is the only trans-membrane selenoprotein in …

[HTML][HTML] Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of …

VA Shchedrina, H Kabil, G Vorbruggen, BC Lee… - Journal of biological …, 2011 - ASBMB
Selenoproteins are essential in vertebrates because of their crucial role in cellular redox
homeostasis, but some invertebrates that lack selenoproteins have recently been identified …