Despite the beneficial effects of prototypical glutamatergic receptor antagonists in animal
models, the pharmacological attempts by the use of such agents have met with very limited …

Neuronal death after ischemia-induced brain damage depends largely upon the activation
of the N-methyl-D-aspartate (NMDA) excitatory glutamate receptor that is a target for many …

Brain insults are a major cause of acute mortality and chronic morbidity. Given the largely
ineffective current therapeutic strategies, the development of new and efficient therapeutic …

Background Xenon, the" inert" gaseous anesthetic, is an antagonist at the N-methyl-D-
aspartate (NMDA)-type glutamate receptor. Because of the pivotal role that NMDA receptors …

Background. Antagonists of the N‐methyl‐d‐aspartate (NMDA) subtype of glutamate
receptors have been shown not only to have neuroprotective effects but also to exhibit …

Short-term exposure of adult rats to nitrous oxide (N2O), an inhalational anesthetic and
NMDA (N-methyl-d-aspartate) antagonist, causes a reversible neurotoxic vacuole reaction in …

IMPLICATIONS: Rats were subjected to temporary focal cerebral ischemia and allowed to
recover for 3 days or 2 wk. There was no effect of intraischemic N 2 O on histologic or …

For the more than 150years that clinicians have been using nitrous oxide (N2O),
researchers continue to struggle over the mechanisms for both its anaesthetic/analgesic …

Measurements and Main Results: Here, we show using multiple models of ex vivo and in
vivo excitotoxic insults and brain ischemia that nitrous oxide, administered alone at …

Recent evidence in primary neuronal cell culture implicates nitric oxide (NO) as a mediator
of glutamatergic neurotoxicity acting via N-methyl-D-aspartate (NMDA) receptors. We find …