BACKGROUND: Several assays have been developed to detect antibodies to aquaporin-4
(NMO-IgG/AQP4-Ab). However, many of these assays require sophisticated techniques and …

BACKGROUND: Recently, a highly specific serum autoantibody was discovered in patients
with neuromyelitis optica, called NMO-IgG, and aquaporin-4, the most abundant water …

Abstract Aquaporin‐4 (AQP 4) is a water channel protein that is most highly, but not
exclusively, expressed in the central nervous system. In 2005 AQP 4 was shown to be the …

Abstract Background: Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory
disorder of the central nervous system of putative autoimmune etiology that primarily affects …

Abstract Background Neuromyelitis optica (NMO, Devic syndrome) is associated with
antibodies to aquaporin-4 (NMO-IgG/AQP4-Ab) in the majority of cases. NMO-IgG/AQP4-Ab …

Background: Antibodies to aquaporin-4 (AQP4-Ab), known as NMO-IgG, are a sensitive and
specific marker for neuromyelitis optica (NMO). Methods: To develop an enzyme-linked …

The current study presents a western blot assay showing good sensitivity (81%) and
specificity (97%) for detecting serum antibodies to Aquaporin-4 (AQP4) in patients with …

Background Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself
with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG …

Six years have elapsed since the publication of the Neuroscience Special Issue entitled
“Brain Water Homeostasis”(Agre et al., 2004). Several of the chapters in the latter Special …

NMO‐I g G against aquaporin‐4 (AQP 4) is a specific marker for neuromyelitis optica (NMO).
We evaluated the performance of different NMO‐I g G detecting methods. In 124 sera (from …