Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study
Purpose Frailty, a phenotype reported among 9.9% of individuals 65 years old and older
(9.6% of women; 5.2% of men), has not been assessed among adult childhood cancer …
(9.6% of women; 5.2% of men), has not been assessed among adult childhood cancer …
Prevalence and predictors of frailty in childhood cancer survivors and siblings: a report from the childhood cancer survivor study
S Hayek, TM Gibson, WM Leisenring… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE To estimate the prevalence of frailty among childhood cancer survivors and to
determine the direct and indirect effects of treatment exposures, lifestyle factors, and severe …
determine the direct and indirect effects of treatment exposures, lifestyle factors, and severe …
Frailty in childhood cancer survivors
Young adult childhood cancer survivors are at an increased risk of frailty, a physiologic
phenotype typically found among older adults. This phenotype is associated with new‐onset …
phenotype typically found among older adults. This phenotype is associated with new‐onset …
Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer
KK Ness, JL Kirkland, MM Gramatges… - Journal of Clinical …, 2018 - ascopubs.org
The improvement in survival of childhood cancer observed across the past 50 years has
resulted in a growing acknowledgment that simply extending the lifespan of survivors is not …
resulted in a growing acknowledgment that simply extending the lifespan of survivors is not …
Frailty index developed from a cancer-specific geriatric assessment and the association with mortality among older adults with cancer
EJ Guerard, AM Deal, YK Chang, GR Williams… - Journal of the National …, 2017 - jnccn.org
Background: An objective measure is needed to identify frail older adults with cancer who
are at increased risk for poor health outcomes. The primary objective of this study was to …
are at increased risk for poor health outcomes. The primary objective of this study was to …
Frailty and aging in cancer survivors
KK Ness, MD Wogksch - Translational Research, 2020 - Elsevier
There are over 15 million survivors of cancer in the United States whose rates of frailty, an
aging phenotype, range from just under 10% to over 80%. Frailty impacts not only disease …
aging phenotype, range from just under 10% to over 80%. Frailty impacts not only disease …
Accelerated aging among cancer survivors: from pediatrics to geriatrics
TO Henderson, KK Ness, HJ Cohen - American Society of Clinical …, 2014 - ascopubs.org
There are almost 14-million cancer survivors in the United States and the population is
growing. Almost two-thirds of these survivors are age 65 or older. Given this, it is imperative …
growing. Almost two-thirds of these survivors are age 65 or older. Given this, it is imperative …
[HTML][HTML] The prevalence and outcomes of frailty in older cancer patients: a systematic review
C Handforth, A Clegg, C Young, S Simpkins… - Annals of oncology, 2015 - Elsevier
Background Frailty is a state of vulnerability to poor resolution of homeostasis following a
stressor event, such as chemotherapy or cancer surgery. Better knowledge of the …
stressor event, such as chemotherapy or cancer surgery. Better knowledge of the …
Association of prediagnostic frailty, change in frailty status, and mortality after cancer diagnosis in the women's health initiative
EMC Feliciano, C Hohensee, AE Rosko… - JAMA network …, 2020 - jamanetwork.com
Importance Understanding changes in frailty in relation to cancer diagnosis can inform
optimal selection of cancer treatments and survivorship care. Objective To investigate …
optimal selection of cancer treatments and survivorship care. Objective To investigate …
Frailty and cancer: current perspectives on assessment and monitoring
V Goede - Clinical interventions in aging, 2023 - Taylor & Francis
Frailty, an age-related condition of increased vulnerability to acute endogenous or
exogenous stressors, is a key barrier to successful treatment of cancer in older people. In …
exogenous stressors, is a key barrier to successful treatment of cancer in older people. In …