The majority of gene loci that have been associated with type 2 diabetes play a role in
pancreatic islet function. To evaluate the role of islet gene expression in the etiology of …

Type 2 diabetes affects over 300 million people, causing severe complications and
premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic …

Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Identifying cis-regulatory elements is important to understanding how human pancreatic
islets modulate gene expression in physiologic or pathophysiologic (eg, diabetic) conditions …

Human genetic studies have emphasised the dominant contribution of pancreatic islet
dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the …

Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, many key …

Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, key tissues …

The intersection of genome-wide association analyses with physiological and functional
data indicates that variants regulating islet gene transcription influence type 2 diabetes …

Type 1 and 2 diabetes (T1/2D) are complex metabolic diseases caused by absolute or
relative loss of functional β-cell mass, respectively. Both diseases are influenced by multiple …

Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain
only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed …