The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These
caspases are activated within multi‐protein inflammasome complexes that assemble in …

For over 15 years the lytic cell death termed pyroptosis was defined by its dependency on
the inflammatory caspase, caspase-1, which, upon pathogen sensing, is activated by innate …

The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5,
and 11 are essential steps in initiating pyroptosis after inflammasome activation. Previous …

Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect
cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase …

Gasdermin-D (also known as GSDMD), the newly identified executioner of pyroptotic cell
death, is cleaved by activated caspase-1 downstream of canonical inflammasome activation …

The inflammasomes are signaling platforms that promote the activation of inflammatory
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …

Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …

Pyroptosis is an inflammatory form of programmed cell death that plays important roles in
immune protection against infections and in inflammatory disorders. Gasdermin D (GSDMD) …

Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and
noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory …