Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathway
S Oon, NJ Wilson, I Wicks - Clinical & translational immunology, 2016 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
impaired immune tolerance, resulting in the generation of pathogenic autoantibodies and …
impaired immune tolerance, resulting in the generation of pathogenic autoantibodies and …
Neutralization of interferon‐α/β–inducible genes and downstream effect in a phase I trial of an anti–interferon‐α monoclonal antibody in systemic lupus erythematosus
Y Yao, L Richman, BW Higgs… - … : Official Journal of …, 2009 - Wiley Online Library
Abstract Objective Type I interferons (IFNs) play an important role in the pathogenesis of
systemic lupus erythematosus (SLE). This phase Ia trial was undertaken to evaluate the …
systemic lupus erythematosus (SLE). This phase Ia trial was undertaken to evaluate the …
Type I interferon in the pathogenesis of systemic lupus erythematosus
M Postal, JF Vivaldo, R Fernandez-Ruiz… - Current opinion in …, 2020 - Elsevier
Highlights•Type I IFN is implicated in SLE pathogenesis by multiple lines of evidence,
including genetics and induction of SLE by IFN treatment.•Nucleic-acid sensing pathways …
including genetics and induction of SLE by IFN treatment.•Nucleic-acid sensing pathways …
Abnormalities of the type I interferon signaling pathway in lupus autoimmunity
S Gallucci, S Meka, AM Gamero - Cytokine, 2021 - Elsevier
Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …
Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic …
Y Yao, BW Higgs, L Richman, B White… - Arthritis research & …, 2010 - Springer
Type I interferons are implicated in the pathogenesis of systemic lupus erythematosus (SLE).
Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the …
Type I interferon-inducible mRNAs are widely and concordantly overexpressed in the …