New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

Key points Anterior and posterior cerebral circulations have differential reactivity to changes
in arterial blood gases, but the implications for the chemoreflex control of breathing are …

Cerebrovascular reactivity to changes in the partial pressure of arterial carbon dioxide (P)
via limiting changes in brain [H+] modulates ventilatory control. It remains unclear, however …

Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

This study examined the effect of high, normal, and uncontrolled end-tidal Pco2 (PetCO2) on
the ventilatory, peak cerebral blood flow velocity (V̄ p), and mean arterial blood pressure …

An important determinant of [H+] in the environment of the central chemoreceptors is
cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a …

New Findings What is the central question of this study? Do differing magnitudes of
ventilation influence cerebrovascular CO2 reactivity and the cerebral blood flow response to …

Key points Central sleep apnoea is a condition characterized by oscillations between
apnoea and hyperpnoea during sleep, which can have many serous health implications …

Both carotid and intracranial chemoreceptors are critical to a normal ventilatory CO 2—H+
chemosensitivity. At low levels of hypercapnia, the carotid contribution is probably greater …