Biomolecular DNP‐Supported NMR Spectroscopy using Site‐Directed Spin Labeling
EAW van Der Cruijsen, EJ Koers… - … A European Journal, 2015 - Wiley Online Library
Dynamic nuclear polarization (DNP) has been shown to greatly enhance spectroscopic
sensitivity, creating novel opportunities for NMR studies on complex and large molecular …
sensitivity, creating novel opportunities for NMR studies on complex and large molecular …
[HTML][HTML] Targeted DNP for biomolecular solid-state NMR
High-field dynamic nuclear polarization is revolutionizing the scope of solid-state NMR with
new applications in surface chemistry, materials science and structural biology. In this …
new applications in surface chemistry, materials science and structural biology. In this …
Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR
T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …
biology. While NMR can provide invaluable information about local geometry on an atomic …
High-temperature dynamic nuclear polarization enhanced magic-angle-spinning NMR
Ü Akbey, AH Linden, H Oschkinat - Applied Magnetic Resonance, 2012 - Springer
Dynamic nuclear polarization (DNP) transfers electron spin-polarization to nuclear spins in
close proximity, increasing sensitivity by two-to-three orders of magnitude. This enables …
close proximity, increasing sensitivity by two-to-three orders of magnitude. This enables …
Exploring protein structures by DNP-enhanced methyl solid-state NMR spectroscopy
J Mao, V Aladin, X Jin, AJ Leeder… - Journal of the …, 2019 - ACS Publications
Although the rapid development of sensitivity-enhanced solid-state NMR (ssNMR)
spectroscopy based on dynamic nuclear polarization (DNP) has enabled a broad range of …
spectroscopy based on dynamic nuclear polarization (DNP) has enabled a broad range of …
[HTML][HTML] A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy
K Herr, M Fleckenstein, M Brodrecht, MV Höfler… - Scientific reports, 2021 - nature.com
A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide
(integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain …
(integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain …
NMR-based structural biology enhanced by dynamic nuclear polarization at high magnetic field
EJ Koers, EAW van Der Cruijsen, M Rosay… - Journal of biomolecular …, 2014 - Springer
Dynamic nuclear polarization (DNP) has become a powerful method to enhance
spectroscopic sensitivity in the context of magnetic resonance imaging and nuclear …
spectroscopic sensitivity in the context of magnetic resonance imaging and nuclear …
High-field dynamic nuclear polarization
B Corzilius - Annual review of physical chemistry, 2020 - annualreviews.org
Dynamic nuclear polarization (DNP) is one of the most prominent methods of sensitivity
enhancement in nuclear magnetic resonance (NMR). Even though solid-state DNP under …
enhancement in nuclear magnetic resonance (NMR). Even though solid-state DNP under …
Cysteine-specific labeling of proteins with a nitroxide biradical for dynamic nuclear polarization NMR
Dynamic nuclear polarization (DNP) enhances the signal in solid-state NMR of proteins by
transferring polarization from electronic spins to the nuclear spins of interest. Typically, both …
transferring polarization from electronic spins to the nuclear spins of interest. Typically, both …
New NMR tools for protein structure and function: Spin tags for dynamic nuclear polarization solid state NMR
R Rogawski, AE McDermott - Archives of biochemistry and biophysics, 2017 - Elsevier
Magic angle spinning solid state NMR studies of biological macromolecules [1–3] have
enabled exciting studies of membrane proteins [4],[5], amyloid fibrils [6], viruses, and large …
enabled exciting studies of membrane proteins [4],[5], amyloid fibrils [6], viruses, and large …