Dopaminergic regulation of protein phosphorylation in the striatum: DARPP-32
HC Hemmings Jr, SI Walaas, CC Ouimet… - Trends in …, 1987 - cell.com
DARPP-32 is a neuronal phosphoprotein that is specifically enriched in neurons possessing
D1 dopamine receptors, including the medium-sized spiny neurons of the striatum. DARPP …
D1 dopamine receptors, including the medium-sized spiny neurons of the striatum. DARPP …
Bidirectional regulation of DARPP-32 phosphorylation by dopamine
A Nishi, GL Snyder, P Greengard - Journal of Neuroscience, 1997 - Soc Neuroscience
Dopamine has been shown to stimulate phosphorylation of DARPP-32, a phosphoprotein
highly enriched in medium-sized spiny neurons of the neostriatum. Here, we investigated …
highly enriched in medium-sized spiny neurons of the neostriatum. Here, we investigated …
DARPP-32, a dopamine-regulated phosphoprotein
HC Hemmings Jr, P Greengard - Progress in brain research, 1986 - Elsevier
Publisher Summary A dopamine-regulated phosphoprotein (DARPP-32) is a
phosphoprotein specifically enriched in dopaminoceptive neurons possessing D-1 …
phosphoprotein specifically enriched in dopaminoceptive neurons possessing D-1 …
DARPP-32: an integrator of neurotransmission
P Svenningsson, A Nishi, G Fisone… - Annu. Rev …, 2004 - annualreviews.org
Dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …
Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons
DARPP-32 (dopamine-and cAMP-regulated phosphoprotein, M r= 32000) is highly
expressed in striatonigral neurons in which its phosphorylation is regulated by several …
expressed in striatonigral neurons in which its phosphorylation is regulated by several …
Regulation of DARPP‐32 dephosphorylation at PKA‐and Cdk5‐sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase‐2A
A Nishi, JA Bibb, S Matsuyama… - Journal of …, 2002 - Wiley Online Library
Glutamatergic inputs from corticostriatal and thalamostriatal pathways have been shown to
modulate dopaminergic signaling in neostriatal neurons. DARPP‐32 (dopamine‐and cAMP …
modulate dopaminergic signaling in neostriatal neurons. DARPP‐32 (dopamine‐and cAMP …
The B″/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A
JH Ahn, JY Sung, T McAvoy, A Nishi… - Proceedings of the …, 2007 - National Acad Sciences
In dopaminoceptive neurons, dopamine-and cAMP-regulated phosphoprotein of 32 kDa
(DARPP-32) plays a central role in integrating the effects of dopamine and other …
(DARPP-32) plays a central role in integrating the effects of dopamine and other …
Glutamate counteracts dopamine/PKA signaling via dephosphorylation of DARPP-32 Ser-97 and alteration of its cytonuclear distribution
A Nishi, M Matamales, V Musante, E Valjent… - Journal of Biological …, 2017 - ASBMB
The interaction of glutamate and dopamine in the striatum is heavily dependent on signaling
pathways that converge on the regulatory protein DARPP-32. The efficacy of dopamine/D1 …
pathways that converge on the regulatory protein DARPP-32. The efficacy of dopamine/D1 …
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades
A Nishi, Y Watanabe, H Higashi… - Proceedings of the …, 2005 - National Acad Sciences
Dopamine-and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) plays a central role
in medium spiny neurons in the neostriatum in the integration of various neurotransmitter …
in medium spiny neurons in the neostriatum in the integration of various neurotransmitter …
Phosphorylation of DARPP‐32 is regulated by GABA in rat striatum and substantia nigra
GL Snyder, G Fisone, P Greengard - Journal of neurochemistry, 1994 - Wiley Online Library
In the medium‐sized spiny neurons of the striatonigral pathway, a cascade of events
involving the activation of dopamine D1 receptors, an increase in cyclic AMP, and activation …
involving the activation of dopamine D1 receptors, an increase in cyclic AMP, and activation …