The mechanisms underlying ethanol-induced activation of the mesolimbic dopamine system
are not fully understood, but increased extracellular dopamine in the nucleus accumbens …

Rationale Cues associated with alcohol can elicit craving, support drug-seeking and
precipitate relapse. Objectives We investigated the possible involvement of nicotinic …

Ethanol shares with all major dependence producing drugs the ability to activate brain
mesocorticolimbic dopamine neurons, an important part of the brain reward systems. This …

Ethanol and nicotine are the most abused drugs, and it is well known that co-abuse of
ethanol and nicotine is frequent in human beings. We have previously obtained results …

Ethanol-induced elevations of accumbal dopamine levels have been linked to the
reinforcing properties of the drug. However, it has not yet been demonstrated where the …

The most commonly abused drugs, alcohol and nicotine, are likely also the most costly
drugs in terms of health and societal costs. A large body of evidence from epidemiological …

Both smoking and alcohol consumption are known to cause severe health problems and
there is an extensive co-abuse of tobacco and ethanol. The reinforcing properties of drugs of …

Aims: Concurrent use of ethanol and nicotine (tobacco) is often seen in human beings. In
previous animal experiments, we have demonstrated that nicotinic acetylcholine receptors …

It was previously demonstrated that the central nicotinic acetylcholine receptor antagonist
mecamylamine perfused in the ventral tegmental area (VTA) counteracts the elevation of …

The mesolimbic dopamine system, originating in the ventral tegmental area (VTA) and
projecting to the nucleus accumbens (NAc), has been heavily implicated in the reinforcing …