A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as
microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with …

Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …

Mutation of DNA mismatch repair genes has rarely been documented in sporadic gastric
carcinoma with microsatellite instability (MSI). In sporadic colorectal carcinoma, hMLH1 …

Microsatellite instability (MSI) in tumors from patients with hereditary non‐polyposis
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …

Microsatellite instability (MSI) is known to result from inactivation of mismatch repair genes
largely by promoter methylation. However, the methylation usually accumulates time …

Changes in the pattern of DNA methylation are among the most common alterations
observed in human cancers, such as gastric carcinomas. We analysed in a series of 51 …

Human cancers with a high frequency microsatellite instability phenotype develop due to
defects in DNA mismatch repair genes. Silencing of a DNA mismatch repair gene, hMLH1 …

Results There were 50 (9.6%) high-frequency MSI (MSI-H) cases. The MSI-H gastric
carcinomas were associated with older age, expanding type by Ming's classification …

Microsatellite instability (MSI) and frameshift mutations in the genes containing coding
nucleotide repeats have been reported in a subset of gastric adenomas, however the …

AIM: To appraise the correlation of mutation and methylation of hMSH1 with microsatellite
instability (MSI) in gastric cancers. METHODS: Mutation of hMLH1 was detected by Two …