Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia
MJ Owen, N Craddock… - Archives of general …, 2010 - jamanetwork.com
This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …
considers future research directions. Until recently, genome-wide scans for dis-ease risk …
The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …
BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …
Genome-wide association studies of schizophrenia: does bigger lead to better results?
SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …
mechanisms leading to manifestation of the disease. New and more effective treatments for …
Genome‐wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness
Genome‐wide association studies (GWAS) of schizophrenia have yielded more than 100
common susceptibility variants, and strongly support a substantial polygenic contribution of …
common susceptibility variants, and strongly support a substantial polygenic contribution of …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …
of heritable disorders caused by different genotypic networks that cause distinct clinical …
Genomewide association for schizophrenia in the CATIE study: results of stage 1
Little is known for certain about the genetics of schizophrenia. The advent of genomewide
association has been widely anticipated as a promising means to identify reproducible DNA …
association has been widely anticipated as a promising means to identify reproducible DNA …
Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain
AL Richards, L Jones, V Moskvina, G Kirov… - Molecular …, 2012 - nature.com
It is widely thought that alleles that influence susceptibility to common diseases, including
schizophrenia, will frequently do so through effects on gene expression. As only a small …
schizophrenia, will frequently do so through effects on gene expression. As only a small …
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
MYM Ng, DF Levinson, SV Faraone, BK Suárez… - Molecular …, 2009 - nature.com
A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide
linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected …
linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected …
Genetics of schizophrenia: ready to translate?
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
understanding of the genetic architecture of schizophrenia. In this review, we consider how …