Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways
CC Zhong, T Zhao, C Hogstrand, F Chen… - The Journal of nutritional …, 2022 - Elsevier
Oxidative stress can induce occurrence of non-alcoholic fatty liver disease (NAFLD). Nrf2 is
a central regulator of cellular oxidative stress and also participates in the control of lipid …
a central regulator of cellular oxidative stress and also participates in the control of lipid …
[HTML][HTML] Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver …
Background and aims Caloric excess and sedentary lifestyles have led to an epidemic of
obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of …
obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of …
Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation
X Feng, W Yu, X Li, F Zhou, W Zhang, Q Shen… - Biochemical …, 2017 - Elsevier
Lipid metabolic disorders and oxidative stress in the liver are key steps in the progression of
nonalcoholic fatty liver disease (NAFLD), which is a major risk factor for the development of …
nonalcoholic fatty liver disease (NAFLD), which is a major risk factor for the development of …
Nuclear factor E2-related factor 2 mediates oxidative stress-induced lipid accumulation in adipocytes by increasing adipogenesis and decreasing lipolysis
Aims: Nuclear factor E2-related factor 2 (Nrf2) is a regulator of cellular oxidative stress and is
also involved in lipid metabolism in adipocytes. However, it remains unknown as to whether …
also involved in lipid metabolism in adipocytes. However, it remains unknown as to whether …
The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism
EE Vomhof-DeKrey, MJ Picklo Sr - The Journal of nutritional biochemistry, 2012 - Elsevier
The nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that responds to
oxidative stress by binding to the antioxidant response element (ARE) in the promoter of …
oxidative stress by binding to the antioxidant response element (ARE) in the promoter of …
Curcumin attenuates ethanol‐induced hepatic steatosis through modulating N rf2/FXR signaling in hepatocytes
C Lu, F Zhang, W Xu, X Wu, N Lian, H Jin, Q Chen… - IUBMB …, 2015 - Wiley Online Library
Alcoholic liver disease (ALD) is a common health problem worldwide, characterized by
aberrant accumulation of lipid in hepatocytes. Inhibition of lipid accumulation has been well …
aberrant accumulation of lipid in hepatocytes. Inhibition of lipid accumulation has been well …
[HTML][HTML] Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression
L Li, J Fu, D Liu, J Sun, Y Hou, C Chen, J Shao… - Redox biology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is an emerging global disease with increasing
prevalence. However, the mechanism of NAFLD development is not fully understood. To …
prevalence. However, the mechanism of NAFLD development is not fully understood. To …
[HTML][HTML] Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
XJ Zhao, HW Yu, YZ Yang, WY Wu, TY Chen, KK Jia… - Redox Biology, 2018 - Elsevier
Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis.
MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 …
MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 …
[HTML][HTML] Emerging role of Nrf2 in adipocytes and adipose biology
KS Schneider, JY Chan - Advances in Nutrition, 2013 - Elsevier
Maintenance of a balanced redox state within the cell is of critical importance to a wide
variety of biological systems. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a critical …
variety of biological systems. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a critical …
Cherry anthocyanins regulate NAFLD by promoting autophagy pathway
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human
health, and present therapies remain limited due to the lack of effective drugs. Lipid …
health, and present therapies remain limited due to the lack of effective drugs. Lipid …