IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis
KA Negrin, RJ Roth Flach, MT DiStefano… - PloS one, 2014 - journals.plos.org
Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is
characterized by increases in both hepatic triglyceride accumulation (denoted as steatosis) …
characterized by increases in both hepatic triglyceride accumulation (denoted as steatosis) …
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice
M Vida, AL Gavito, FJ Pavón… - Disease models & …, 2015 - journals.biologists.com
ABSTRACT Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid
metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to …
metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to …
Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability
O Nov, H Shapiro, H Ovadia, T Tarnovscki, I Dvir… - PloS one, 2013 - journals.plos.org
The inflammasome has been recently implicated in obesity-associated dys-metabolism.
However, of its products, the specific role of IL-1β was clinically demonstrated to mediate …
However, of its products, the specific role of IL-1β was clinically demonstrated to mediate …
Mesenteric fat lipolysis mediates obesity-associated hepatic steatosis and insulin resistance
Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders
and are tightly associated with obesity and type 2 diabetes. However, the underlying …
and are tightly associated with obesity and type 2 diabetes. However, the underlying …
[HTML][HTML] Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
AH Clementi, AM Gaudy, N Van Rooijen… - … et Biophysica Acta (BBA …, 2009 - Elsevier
While adipose tissue-associated macrophages contribute to development of chronic
inflammation and insulin resistance of obesity, little is known about the role of hepatic …
inflammation and insulin resistance of obesity, little is known about the role of hepatic …
Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients
X Pan, P Wang, J Luo, Z Wang, Y Song, J Ye, X Hou - Endocrine, 2015 - Springer
Non-alcoholic fatty liver disease (NAFLD) is characterized by steatosis associated with liver
inflammation. As NAFLD progresses, triglycerides increase within hepatocytes, causing …
inflammation. As NAFLD progresses, triglycerides increase within hepatocytes, causing …
Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice
MC Stanton, SC Chen, JV Jackson… - Journal of …, 2011 - Springer
Background Obesity and inflammation are highly integrated processes in the pathogenesis
of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular …
of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular …
Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice
L Zhao, S Zhong, H Qu, Y Xie, Z Cao, Q Li, P Yang… - Scientific reports, 2015 - nature.com
The prevalence of nonalcoholic fatty liver disease (NAFLD) increases with increasing body
mass index (BMI). However, approximately 40–50% of obese adults do not develop hepatic …
mass index (BMI). However, approximately 40–50% of obese adults do not develop hepatic …
Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice
The interaction between fat deposition and inflammation during obesity contributes to the
development of non-alcoholic fatty liver disease (NAFLD). The present study examined the …
development of non-alcoholic fatty liver disease (NAFLD). The present study examined the …
[PDF][PDF] Inflammation‐associated interleukin‐6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in …
Alcoholic and nonalcoholic steatohepatitis are characterized by fatty liver plus inflammation.
It is generally believed that steatosis promotes inflammation, whereas inflammation in turn …
It is generally believed that steatosis promotes inflammation, whereas inflammation in turn …