Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases,
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

Communication within the glial cell ecosystem is essential for neuronal and brain health,–.
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …

Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …

Alzheimer's disease is an incurable neurodegenerative disorder in which neuroinflammation
has a critical function. However, little is known about the contribution of the adaptive immune …

Inflammation is a pathological hallmark of Alzheimer's disease, and innate immune cells
have been shown to contribute to disease pathogenesis. In two transgenic models of …