Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
Disease-associated astrocyte epigenetic memory promotes CNS pathology
Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases,
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease
Communication within the glial cell ecosystem is essential for neuronal and brain health,–.
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …
A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis
Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease
Alzheimer's disease is an incurable neurodegenerative disorder in which neuroinflammation
has a critical function. However, little is known about the contribution of the adaptive immune …
has a critical function. However, little is known about the contribution of the adaptive immune …
Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
E Zenaro, E Pietronigro, VD Bianca, G Piacentino… - Nature medicine, 2015 - nature.com
Inflammation is a pathological hallmark of Alzheimer's disease, and innate immune cells
have been shown to contribute to disease pathogenesis. In two transgenic models of …
have been shown to contribute to disease pathogenesis. In two transgenic models of …