The treatment of metastatic melanoma with chemotherapy and biologies
MB Atkins - Current Opinion in Oncology, 1997 - journals.lww.com
Metastatic malignant melanoma remains a frustrating and almost invariably fatal disease.
Nonetheless, both cytotoxic chemotherapy and immunotherapy agents have shown activity …
Nonetheless, both cytotoxic chemotherapy and immunotherapy agents have shown activity …
[HTML][HTML] Evolving impact of long-term survival results on metastatic melanoma treatment
O Michielin, MB Atkins, HB Koon… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Melanoma treatment has been revolutionized over the past decade. Long-term results with
immuno-oncology (IO) agents and targeted therapies are providing evidence of durable …
immuno-oncology (IO) agents and targeted therapies are providing evidence of durable …
Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations
JA Seidel, A Otsuka, K Kabashima - Frontiers in oncology, 2018 - frontiersin.org
Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
Beyond CTLA-4 and PD-1 inhibition: novel immune checkpoint molecules for melanoma treatment
Simple Summary Although the incorporation of immune checkpoint inhibitors (ICIs) in
melanoma treatment has significantly improved prognosis for patients with advanced …
melanoma treatment has significantly improved prognosis for patients with advanced …
[HTML][HTML] Melanoma as a model tumour for immuno-oncology
M Maio - Annals of Oncology, 2012 - Elsevier
Melanoma is one of the most aggressive forms of skin cancer. Furthermore, incidence rates
are increasing. Until recently, no agent had been shown to improve survival over supportive …
are increasing. Until recently, no agent had been shown to improve survival over supportive …
Combined targeted therapy and immunotherapy in melanoma: a review of the impact on the tumor microenvironment and outcomes of early clinical trials
MS Pelster, RN Amaria - Therapeutic advances in medical …, 2019 - journals.sagepub.com
The development of BRAF and MEK inhibitors (BRAFis and MEKis) and immune checkpoint
inhibitors have changed the management of advanced stage melanoma and improved the …
inhibitors have changed the management of advanced stage melanoma and improved the …
Modern aspects of immunotherapy with checkpoint inhibitors in melanoma
V Petrova, I Arkhypov, R Weber, C Groth… - International Journal of …, 2020 - mdpi.com
Although melanoma is one of the most immunogenic tumors, it has an ability to evade anti-
tumor immune responses by exploiting tolerance mechanisms, including negative immune …
tumor immune responses by exploiting tolerance mechanisms, including negative immune …
The rapidly evolving therapies for advanced melanoma—Towards immunotherapy, molecular targeted therapy, and beyond
Z Zhu, W Liu, V Gotlieb - Critical reviews in oncology/hematology, 2016 - Elsevier
The incidence of melanoma in both males and females continues to rise during the past 40
years despite the stable or declining trends for most cancer types. Due to the tremendous …
years despite the stable or declining trends for most cancer types. Due to the tremendous …
[HTML][HTML] Combining targeted therapy and immune checkpoint inhibitors in the treatment of metastatic melanoma
Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than
any other solid tumor. Metastatic melanoma treatment has considerably progressed in the …
any other solid tumor. Metastatic melanoma treatment has considerably progressed in the …
Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment
M Marzagalli, ND Ebelt, ER Manuel - Seminars in cancer biology, 2019 - Elsevier
Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …
rapidly increasing in the past decades. Melanomas are among the most immunogenic …