Metastatic malignant melanoma remains a frustrating and almost invariably fatal disease.
Nonetheless, both cytotoxic chemotherapy and immunotherapy agents have shown activity …

Melanoma treatment has been revolutionized over the past decade. Long-term results with
immuno-oncology (IO) agents and targeted therapies are providing evidence of durable …

Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …

Simple Summary Although the incorporation of immune checkpoint inhibitors (ICIs) in
melanoma treatment has significantly improved prognosis for patients with advanced …

Melanoma is one of the most aggressive forms of skin cancer. Furthermore, incidence rates
are increasing. Until recently, no agent had been shown to improve survival over supportive …

The development of BRAF and MEK inhibitors (BRAFis and MEKis) and immune checkpoint
inhibitors have changed the management of advanced stage melanoma and improved the …

Although melanoma is one of the most immunogenic tumors, it has an ability to evade anti-
tumor immune responses by exploiting tolerance mechanisms, including negative immune …

The incidence of melanoma in both males and females continues to rise during the past 40
years despite the stable or declining trends for most cancer types. Due to the tremendous …

Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than
any other solid tumor. Metastatic melanoma treatment has considerably progressed in the …

Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …