Convincing evidence accumulated over the last decades demonstrates the crucial role of
epigenetic modifications for mammalian genome regulation and its flexibility. DNA …

There are numerous examples of parental transgenerational inheritance that is epigenetic.
The informational molecules include RNA, chromatin modifications, and cytosine …

DNA methylation is a conspicuous feature of vertebrate genomes. Approximately 4% of total
cytosines are methylated, representing about 5 x 107 5-methylcytosine (5-mC) residues per …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

DNA methylation patterns have profound impacts on genome stability, gene expression and
development. The molecular base of DNA methylation patterns has long been focused at …

ABSTRACT DNA cytosine-5 methylation is a well-studied epigenetic pathway implicated in
gene expression control and disease pathogenesis. Different technologies have been …

This chapter presents a personal account of the work on DNA methylation in viral and
mammalian systems performed in the author's laboratory in the course of the past thirty …

The extent of the DNA methylation of genomic DNA as well as the methylation pattern of
many gene-regulatory areas are important aspects with regard to the state of genetic …

DNA methylation is the best-studied epigenetic modification and altered DNA methylation
patterns have been identified in cancer and many other complex diseases. The first DNA …

Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …