[HTML][HTML] Gβ association and effector interaction selectivities of the divergent Gγ subunit Gγ13

BL Blake, MR Wing, JY Zhou, Q Lei, JR Hillmann… - Journal of Biological …, 2001 - ASBMB
Gγ 13 is a divergent member of the Gγ subunit family considered to be a component of the
gustducin G-protein heterotrimer involved in bitter and sweet taste reception in taste bud …

RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells

L Von Buchholtz, A Elischer, E Tareilus… - European Journal of …, 2004 - Wiley Online Library
G‐protein‐mediated signalling processes are involved in sweet and bitter taste transduction.
In particular, the G protein α‐subunit gustducin has been implicated in these processes. One …

Comprehensive study on G protein α-subunits in taste bud cells, with special reference to the occurrence of Gαi2 as a major Gα species

Y Kusakabe, A Yasuoka, M Asano-Miyoshi… - Chemical …, 2000 - academic.oup.com
Previous studies have identified many cDNA species that encode a variety of G protein α-
subunits occurring in taste buds. These include the cDNA encoding a taste-bud-specific Gα …

[HTML][HTML] Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue

M Tizzano, G Dvoryanchikov, JK Barrows, S Kim… - BMC neuroscience, 2008 - Springer
Abstract Background" Type II"/Receptor cells express G protein-coupled receptors (GPCRs)
for sweet, umami (T1Rs and mGluRs) or bitter (T2Rs), as well as the proteins for …

Functional interaction between T2R taste receptors and G-protein α subunits expressed in taste receptor cells

T Ueda, S Ugawa, H Yamamura… - Journal of …, 2003 - Soc Neuroscience
Bitter taste perception is a conserved chemical sense against the ingestion of poisonous
substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called …

[HTML][HTML] Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling

CJ Fenech, DS Kerr, S Grall, Z Liu… - Frontiers in cellular …, 2009 - frontiersin.org
Taste receptors for sweet, bitter and umami tastants are G-protein coupled receptors
(GPCRs). While much effort has been devoted to understanding G-protein-receptor …

[HTML][HTML] Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia

SP Cohen, BK Buckley, M Kosloff, AL Garland… - Journal of Biological …, 2012 - ASBMB
The gustatory system detects tastants and transmits signals to the brain regarding ingested
substances and nutrients. Although tastant receptors and taste signaling pathways have …

[HTML][HTML] Identification of two α-subunit species of GTP-binding proteins, Gα15 and Gαq, expressed in rat taste buds

Y Kusakabe, E Yamaguchi, K Tanemura… - … et Biophysica Acta (BBA …, 1998 - Elsevier
We cloned cDNAs for two G protein α-subunits belonging to the Gαq family, each capable of
activating PLCβ, from rat tongue. One is a Gαq in the narrow sense, and the other, termed rat …

Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish

M Ohmoto, S Okada, S Nakamura… - Journal of …, 2011 - Wiley Online Library
A comprehensive reevaluation of the G protein alpha subunit genes specifically expressed
in taste buds in the tongue epithelium of rodents revealed that Gq and G14 of the Gq class …

Gβ3 forms distinct dimers with specific Gγ subunits and preferentially activates the β3 isoform of phospholipase C

LSW Poon, ASL Chan, YH Wong - Cellular signalling, 2009 - Elsevier
Heterotrimeric G proteins regulate multiple effectors of which some are mediated via the Gβγ
dimers. There is evidence to suggest that the functions of Gβγ dimers are not shared by all …