The interaction of bacterial pathogens with their hosts' innate immune systems can be
extremely complex and is often difficult to disentangle experimentally. Using mouse models …

The ability to manipulate animal hosts as well as bacterial pathogens greatly expands the
utility of in vivo models of infection. For example, the construction of mice that harbor human …

Mouse genetics is a powerful tool for the dissection of genes, proteins, and pathways
important in biological processes. Application of this approach to study the host response to …

Several strains of the human opportunistic pathogen Pseudomonas aeruginosa infect
plants, nematodes and insects. Our laboratory has developed a multihost pathogenesis …

▪ Abstract To decipher the complexity of host-pathogen interactions the widest possible
range of model hosts and of analytical methods is required. As some virulence mechanisms …

Infectious diseases are the second leading cause of death worldwide. Although the host
multitropism of some pathogens has rendered their manipulation possible in animal models …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is one of the oldest
and most successful pathogens in the world. Diverse selective pressures encountered within …

The innate immune system is an ancient and broad-spectrum defense system found in all
eukaryotes. The detection of microbial elicitors results in the up-regulation of defense …

Although the role of host heredity in susceptibility to infectious diseases is significant, the
genetic control of immunity to infection remains poorly understood. Advances in …

Genetic factors strongly determine the outcome of infectious diseases caused by various
pathogens. The molecular mechanisms of resistance and susceptibility in humans, however …