Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies

A Grimm, I Lejri, F Hallé, M Schmitt… - Journal of …, 2020 - Wiley Online Library
Translocator protein 18 kDa (TSPO) is a mitochondrial protein located in the outer
membrane and involved in cholesterol translocation, a prerequisite for steroid biosynthesis …

[HTML][HTML] TSPO ligands boost mitochondrial function and pregnenolone synthesis

I Lejri, A Grimm, F Hallé, M Abarghaz… - Journal of …, 2019 - content.iospress.com
Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and
plays an important role in steroidogenesis and cell survival. In the central nervous system …

Therapeutic actions of translocator protein (18 kDa) ligands in experimental models of psychiatric disorders and neurodegenerative diseases

BD Arbo, F Benetti, LM Garcia-Segura… - The Journal of steroid …, 2015 - Elsevier
Translocator protein (TSPO) is an 18 kDa protein located at contact sites between the outer
and the inner mitochondrial membrane. Numerous studies have associated TSPO with the …

The translocator protein (18 kDa) and its role in neuropsychiatric disorders

T Barichello, LR Simoes, A Collodel… - Neuroscience & …, 2017 - Elsevier
Translocator protein (TSPO) is an 18 kDa translocator membrane protein expressed in the
outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral …

Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells

S Bader, L Wolf, VM Milenkovic, M Gruber… - …, 2019 - Elsevier
The translocator protein 18 kDa (TSPO), initially characterized as peripheral
benzodiazepine receptor, is a conserved outer mitochondrial membrane protein, implicated …

A protective role of translocator protein in Alzheimer's disease brain

ME Jung - Current Alzheimer Research, 2020 - ingentaconnect.com
Translocator Protein (18 kDa)(TSPO) is a mitochondrial protein that locates cytosol
cholesterol to mitochondrial membranes to begin the synthesis of steroids including …

Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders

R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Targeting mitochondrial energy metabolism with TSPO ligands

P Gut - Biochemical Society Transactions, 2015 - portlandpress.com
The translocator protein (18 kDa)(TSPO) resides on the outer mitochondrial membrane
where it is believed to participate in cholesterol transport and steroid hormone synthesis …

Translocator protein (18 kDa): an update on its function in steroidogenesis

V Papadopoulos, J Fan, B Zirkin - Journal of …, 2018 - Wiley Online Library
Translocator protein (18 kDa)(TSPO) is a ubiquitous mitochondrial protein. Studies of its
responses to drug and endogenous ligands have shown TSPO to be involved either directly …

Translocator protein: pharmacology and steroidogenesis

A Midzak, B Zirkin… - Biochemical Society …, 2015 - portlandpress.com
The translocator protein (TSPO; 18k Da) is an evolutionarily conserved outer mitochondrial
membrane (OMM) protein highly expressed in steroid-synthesizing cells and found to …