Alzheimer's disease (AD) is a complex neurodegenerative disorder, which involves many
underlying pathological processes. Recently, it has been demonstrated that AD also …

It is becoming evident that chronic exposure to stress not only might result in insulin
resistance or cognitive deficits, but may also be considered a risk factor for pathologies such …

Alzheimer's disease (AD) is associated with disturbances in blood glucose regulation, and
type-2 diabetes elevates the risk for dementia. A role for amyloid-β peptide (Aβ) in linking …

Background Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously
overproduce Aβ without non-physiological overexpression of amyloid precursor protein …

It is frequently argued that both amyloid beta (Aβ) and oxidative stress are involved in the
pathogenesis of Alzheimer's disease (AD). We show here that clonal nerve cell lines and …

Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD),
only one protective mutation has been identified so far in humans. Here we identify possible …

Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-
dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice …

During aging, lifestyle-related factors shape the brain's response to insults and modulate the
progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the …

Recent studies suggest that hyperinsulinemia and insulin resistance are linked to
Alzheimer's disease (AD). In this study, we used Tg2576 transgenic (Tg) mice, a widely used …

We previously reported that mice over-expressing the human amyloid precursor protein
gene with the double Swedish mutation of familial Alzheimer's disease (mtAPP), which …