A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …

Background Middle age obesity is recognized as a risk factor for Alzheimer's disease (AD)
although a mechanistic linkage remains unclear. Based upon the fact that obese adipose …

Age remains the main risk factor for developing Alzheimer's disease (AD) although certain
metabolic alterations, including prediabetes and type 2 diabetes (T2D), may also increase …

Growing evidence indicates that physical and psychosocial stressors, in part acting through
the hypothalamic-pituitary-adrenal (HPA) axis, may accelerate the process of Alzheimer's …

Alzheimer's disease (AD) is characterized by increased β amyloid (Aβ) levels, extracellular
Aβ deposits in senile plaques, neurofibrillary tangles, and neuronal loss. However, the …

Mounting evidence from clinical, epidemiological, neuropathology and preclinical studies
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …

It is lay knowledge now that Alzheimer's dementia (AD) is one of the most devastating
diseases afflicting our societies. A major thrust in search for a cure has relied in the …

In vulnerable individuals, chronic and persistent stress is an established risk factor for
disorders that are comorbid with Alzheimer's disease (AD), such as hypertension, obesity …

Alzheimer disease (AD) is a neurodegenerative disease affecting a large percentage of the
elderly population. Preventative therapies for AD have been limited; however …

Insulin resistance and diabetes mellitus are major risk factors for Alzheimer's disease (AD),
and studies with transgenic mouse models of AD have provided supportive evidence with …