The abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the
development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the …

In parallel to imaging studies in humans with Alzheimer's disease (AD), we have mapped
brain metabolic activity in transgenic mouse models of AD. Our aim in both is to provide new …

Increasing evidence suggests an important role of mitochondrial dysfunction in the
pathogenesis of Alzheimer's disease. Thus, we investigated the effects of acute and chronic …

Age remains the main risk factor for developing Alzheimer's disease (AD) although certain
metabolic alterations, including prediabetes and hyperinsulinemia, also increase this risk …

Amyloid β-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of
short chain dehydrogenase/reductases whose distinctive properties include the capacity to …

The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently
associated with a number of characteristic histopathological, molecular, and biochemical …

Aberrant cortisol and activation of the glucocorticoid receptor (GR) play an essential role in
age-related progression of Alzheimer's disease (AD). However, the GR pathways required …

Nosologically, Alzheimer's disease (AD) is not a single disorder. Missense gene mutations
involved in increased formation of the amyloid-β protein precursor derivatives amyloid-β …

The deficits characteristic of Alzheimer's disease (AD) are believed to result, at least in part,
from the neurotoxic effects of β-amyloid peptides, a set of 39–43 amino acid fragments …

Point mutations within the β-amyloid precusor protein (β-APP) gene known to segregate with
Alzheimer's disease in certain families were introduced into human β-APP cDNAs and …