Alzheimer's disease (AD) has characteristic neuropathological abnormalities including
regionalized neurodegeneration, neurofibrillary tangles, amyloid beta (Aβ) deposition …

Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of …

The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent
oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of …

Alzheimer's disease (AD) is associated with brain insulin resistance and insulin deficiency,
whereas Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance …

Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression
of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To …

Insulin plays an important role in memory and other aspects of brain function. The insulin
resistance syndrome, characterized by chronic peripheral insulin elevations, reduced insulin …

Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type
II diabetes [a non‐insulin dependent form of diabetes mellitus (NIDDM)], is associated with …

Although increased lifespan is associated with reduced insulin signaling, insulin signaling is
essential for neuronal development and survival. Insulin resistance is central to Type II …

Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the
accumulation of amyloid-ß (Aß) peptide in the brain. Objective: To gain a better insight into …

The amyloid precursor protein (APP) is a type I transmembrane glycoprotein widely studied
for its role as the source of β-amyloid peptide, accumulation of which is causal in at least …