This study assessed the extent to which high fat diet (HFD)-induced β-amyloid accumulation
and cognitive decline in APP/PSEN1 mice are reversible through control of fat intake. Ten …

Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …

Peripheral insulin resistance is associated with hyperinsulinemia, which may be associated
with brain insulin deficiency that is characteristic of sporadic Alzheimer's disease (sAD) …

Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain's
parenchyma and is a key histopathological hallmark of Alzheimer's disease (AD). Work on …

In brains from patients with Alzheimer's disease (AD), expression of insulin receptor (IR),
insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate proteins is …

Amyloid precursor protein (APP) mis‐processing and aberrant tau hyperphosphorylation are
causally related to the pathogenesis and neurodegenerative processes that characterize …

Although chronic stress is known to be linked with memory and other neurological disorders,
little is known about the relationship between chronic stress and the onset or development of …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its
etiology is still not completely understood. The identification of underlying pathological …

Background Alzheimer's disease (AD), the most common cause of dementia, is
characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary …

Mutations in amyloid precursor protein (APP) have been most intensely studied in brain
tissue for their link to Alzheimer's disease (AD) pathology. However, APP is highly …