Cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-dependent airway
epithelial bicarbonate transport is hypothesized to participate in airway surface liquid pH …

Because the defect in Cl-secretion exhibited by cystic fibrosis (CF) epithelia reflects
regulatory rather than conductive abnormalities of an apical membrane Cl-channel, we …

Cystic fibrosis (CF) is caused by the loss of functional CFTR Cl− channels. However, it is not
understood how this defect disrupts salt and liquid movement in the airway or whether it …

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …

Two Cl− conductances have been described in the apical membrane of both human and
murine proximal airway epithelia that are thought to play predominant roles in airway …

The pathogenesis of cystic fibrosis (CF) airways infection is unknown. Two hypotheses,"
hypotonic [low salt]/defensin" and" isotonic volume transport/mucus clearance," attempt to …

Prior studies have shown that fluid secretions from airway submucosal glands in cystic
fibrosis (CF) are reduced and hyperviscous, possibly contributing to the pathogenesis of CF …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) protein, an epithelial chloride channel expressed in the airways, pancreas, testis …

Cultured normal and cystic fibrosis (CF) airway epithelia were exposed to 5'-(N-
ethylcarboxamido)-adenosine (NECA), ATP, or ionomycin. NECA activated a sustained, 4, 4' …

CFTR is a cAMP-activated chloride and bicarbonate channel that is critical for lung
homeostasis. Decreases in CFTR expression have dire consequences in cystic fibrosis (CF) …