Designing microorganisms for heterologous biosynthesis of cannabinoids

 Carvalho, EH Hansen, O Kayser… - FEMS yeast …, 2017 - academic.oup.com
During the last decade, the use of medical Cannabis has expanded globally and legislation
is getting more liberal in many countries, facilitating the research on cannabinoids. The …

A bio-inspired cell-free system for cannabinoid production from inexpensive inputs

MA Valliere, TP Korman, MA Arbing… - Nature Chemical …, 2020 - nature.com
Moving cannabinoid production away from the vagaries of plant extraction and into
engineered microbes could provide a consistent, purer, cheaper and environmentally …

[PDF][PDF] Recent advances in cannabinoid biochemistry and biotechnology

F Taura, R Tanaya, S Sirikantaramas - Science Asia, 2019 - researchgate.net
Cannabinoids, produced only in Cannabis sativa, are meroterpenoid secondary metabolites
composed of monoterpene and polyketide moieties. Numerous cannabinoids have been …

Engineering yeasts as platform organisms for cannabinoid biosynthesis

B Zirpel, F Degenhardt, C Martin, O Kayser… - Journal of …, 2017 - Elsevier
Abstract Δ 9-tetrahydrocannabinolic acid (THCA) is a plant derived secondary natural
product from the plant Cannabis sativa l. The discovery of the human endocannabinoid …

Parallel evolution of cannabinoid biosynthesis

P Berman, LA de Haro, A Jozwiak, S Panda, Z Pinkas… - Nature plants, 2023 - nature.com
Modulation of the endocannabinoid system is projected to have therapeutic potential in
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …

Current status and future prospects in cannabinoid production through in vitro culture and synthetic biology

M Hesami, M Pepe, A Baiton, AMP Jones - Biotechnology Advances, 2023 - Elsevier
For centuries, cannabis has been a rich source of fibrous, pharmaceutical, and recreational
ingredients. Phytocannabinoids are the most important and well-known class of cannabis …

[HTML][HTML] Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow

WM Shaw, Y Zhang, X Lu, AS Khalil, G Ladds… - Nature …, 2022 - nature.com
Microbial production of cannabinoids promises to provide a consistent, cheaper, and more
sustainable supply of these important therapeutic molecules. However, scaling production to …

[HTML][HTML] Biosynthesis of nature-inspired unnatural cannabinoids

KJH Lim, YP Lim, YD Hartono, MK Go, H Fan, WS Yew - Molecules, 2021 - mdpi.com
Natural products make up a large proportion of medicine available today. Cannabinoids
from the plant Cannabis sativa is one unique class of meroterpenoids that have shown a …

Cannabinoids: biosynthesis and biotechnological applications

S Sirikantaramas, F Taura - Cannabis sativa L.-Botany and biotechnology, 2017 - Springer
Cannabinoids are unique terpenophenolic metabolites found only in Cannabis sativa. The
biosynthetic mechanism of these compounds had long been ambiguous since conventional …

[HTML][HTML] The biochemistry of phytocannabinoids and metabolic engineering of their production in heterologous systems

K Blatt-Janmaat, Y Qu - International Journal of Molecular Sciences, 2021 - mdpi.com
The medicinal properties of cannabis and the its legal status in several countries and
jurisdictions has spurred the massive growth of the cannabis economy around the globe …