Background: Symptomatic remission is the optimal outcome in depression. A brief, validated
tool for symptom measurement that can indicate when remission has occurred in mental …

Objectives: To examine the available scientific literature for answers to clinically relevant
questions regarding the effectiveness and tolerability of antidepressant drugs (ADs) for the …

The objective of this re-analysis of the European Genome-Based Therapeutic Drugs for
Depression Study (GENDEP) was to psychometrically test the unidimensionality of the full …

Background A variety of depression rating scales are currently used in clinical and research
practice. As these scales are generally thought to correlate well, there may be some benefit …

Objective: To compare the efficacy and tolerability of tricyclic antidepressants with selective
serotonin reuptake inhibitors in depression in primary care. Design: Systematic review and …

Background: Studies attempting to identify predictors of antidepressant response in patients
with major depression have reported inconsistent results. One explanation may be the …

BACKGROUND: Numerous reviews and meta-analyses of the antidepressant literature in
major depressive disorders (MDD), both acute and maintenance, have been published …

Background Conventional meta-analyses have shown inconsistent results for efficacy of
second-generation antidepressants. We therefore did a multiple-treatments meta-analysis …

Introduction Pharmacotherapy plays an important role in the treatment of major depression.
At the initiation of antidepressant treatment, both improvement of symptoms in the short term …

Objectives To provide a succinct, clinically useful summary of the management of major
depression, based on the 2020 Royal Australian and New Zealand College of Psychiatrists …