Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment
Cancer is a challenging and second most deadly disease. The epidermal growth factor
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
In silico and in vitro evaluations of fluorophoric thiazolo-[2, 3-b] quinazolinones as anti-cancer agents targeting EGFR-TKD
Epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) plays a pivotal role in
cellular signaling, growth, and metabolism. The EGFR-TKD is highly expressed in cancer …
cellular signaling, growth, and metabolism. The EGFR-TKD is highly expressed in cancer …
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4, 5-dihydropyrazoles as anticancer agents with …
Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …
especially those associated with human malignancies. This created the urge to develop …
Novel 2-(5-Aryl-4, 5-dihydropyrazol-1-yl) thiazol-4-one as EGFR inhibitors: synthesis, biological assessment and molecular docking insights
Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
[HTML][HTML] Structural insights into conformational stability and binding of thiazolo-[2, 3-b] quinazolinone derivatives with EGFR-TKD and in-vitro study
Heterocyclic molecules are well-known drugs against various diseases including cancer.
Many tyrosine kinase inhibitors including erlotinib, osimertinib, and sunitinib were …
Many tyrosine kinase inhibitors including erlotinib, osimertinib, and sunitinib were …
Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New Thiazolidinone‐Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and …
S Magdy Eldaly, D Salama Zakaria… - Chemistry & …, 2023 - Wiley Online Library
Synthesis of new anticancer candidates with protein kinases inhibitory potency is a major
goal of pharmaceutical science and synthetic research. This current work represents the …
goal of pharmaceutical science and synthetic research. This current work represents the …
Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological …
SM Al-Muntaser, AA Al-Karmalawy, AM El-Naggar… - RSC …, 2023 - pubs.rsc.org
In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …
Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo [3, 4-d] Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell …
A series of novel hybrid pyrazolo [3, 4-d] pyramidine derivatives was designed and
chemically synthesized in useful yields. The synthesized compounds were structurally …
chemically synthesized in useful yields. The synthesized compounds were structurally …
Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido [2, 3-d] pyrimidine derivatives targeting epidermal growth factor receptor
J Hou, S Wan, G Wang, T Zhang, Z Li, Y Tian… - European Journal of …, 2016 - Elsevier
Three series of novel quinazoline and pyrido [2, 3-d] pyrimidine derivatives were designed,
synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and a panel of five …
synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and a panel of five …
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