Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido [2, 3-d] pyrimidine derivatives targeting epidermal growth factor receptor
J Hou, S Wan, G Wang, T Zhang, Z Li, Y Tian… - European Journal of …, 2016 - Elsevier
Three series of novel quinazoline and pyrido [2, 3-d] pyrimidine derivatives were designed,
synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and a panel of five …
synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and a panel of five …
Design, synthesis, molecular modeling, and biological evaluations of novel chalcone based 4-Nitroacetophenone derivatives as potent anticancer agents targeting …
A series of chalcone-based 4-Nitroacetophenone derivatives were designed and
synthesized by the single-step condensation method. These compounds were identified by …
synthesized by the single-step condensation method. These compounds were identified by …
Dual kinase inhibition of EGFR/HER2: design, synthesis and molecular docking of thiazolylpyrazolyl‐based aminoquinoline derivatives as anticancer agents
RZ Batran, WA El‐Kashak, SM El‐Daly… - …, 2021 - Wiley Online Library
Two new series of aminoquinoline based derivatives (thiazolyl pyrazolines and pyrazolyl
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …
Novel benzothiazole hybrids targeting EGFR: Design, synthesis, biological evaluation and molecular docking studies
EA Abd El-Meguid, GO Moustafa, HM Awad… - Journal of Molecular …, 2021 - Elsevier
Novel benzo [d] thiazole-based analogues were synthesized with the aim of screening their
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …
EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives
AAE Mourad, NA Farouk, ESH El-Sayed, ARE Mahdy - Life Sciences, 2021 - Elsevier
Aims EGFR and VEGFR-2 have emerged as promising targets for cancer management as
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
In vitro and in silico evaluation of new thieno [2, 3-d] pyrimidines as anti-cancer agents and apoptosis inducers targeting VEGFR-2
SA El-Metwally, AA Abuelkhir, H Elkady… - … Biology and Chemistry, 2023 - Elsevier
In this study, new thieno [2, 3-d] pyrimidine derivatives that could have potential anticancer
activity by inhibiting the VEGFR-2 receptor have been designed, synthesized, and …
activity by inhibiting the VEGFR-2 receptor have been designed, synthesized, and …
Identification and exploration of quinazoline-1, 2, 3-triazole inhibitors targeting EGFR in lung cancer
Epidermal growth factor receptor (EGFR) enhances lung cancer development, due to their
inability to permeate the cell membrane, secreted growth factors work through specialized …
inability to permeate the cell membrane, secreted growth factors work through specialized …
Synthesis, biological evaluation and molecular modeling study of [1, 2, 4]-Triazolo [4, 3-c] quinazolines: New class of EGFR-TK inhibitors
Abstract New series of triazolo [4, 3-c] quinazolines were designed, synthesized and their
structures were elucidated using different spectroscopic techniques. They were evaluated …
structures were elucidated using different spectroscopic techniques. They were evaluated …
Synthesis and Biological Evaluation of Benzo [d] thiazolyl‐Sulfonyl‐Benzo [4, 5] isothiazolo [2, 3‐c][1, 2, 3] triazole Derivatives as EGFR Targeting Anticancer Agents
E Ramya Sucharitha, S Kumar Nukala… - …, 2023 - Wiley Online Library
A one‐step procedure for the synthesis of new fused Benzo [d] thiazolo‐1, 2, 3‐triazoles (3 a–
3 h and 4 a–4 h) in good yields using sulfonylazides (2) and iodoalkyne (1) through from the …
3 h and 4 a–4 h) in good yields using sulfonylazides (2) and iodoalkyne (1) through from the …
6-Bromo quinazoline derivatives as cytotoxic agents: design, synthesis, molecular docking and MD simulation
Based on unselectively, several side effects and drug resistance of available anticancer
agents, the development and research for novel anticancer agents is necessary. In this …
agents, the development and research for novel anticancer agents is necessary. In this …